It determines 28-Across: Abbr

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Possible Answers: DOB.

Random information on the term “DOB”:

Dimethoxybromoamphetamine (DOB), also known as Brolamfetamine and Bromo-DMA, is a psychedelic drug and substituted amphetamine of the phenethylamine class of compounds. DOB was first synthesized by Alexander Shulgin in 1967.[1] Its synthesis and effects are documented in Shulgin’s book PiHKAL: A Chemical Love Story.
Taken from Wikipedia