Now we are looking on the crossword clue: With 18-Down, exclamation in ‘Frankenstein’.
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Possible Answers: ITS.
Random information on the term “ITS”:
ITS, the Incompatible Timesharing System (named in comparison with the Compatible Time-Sharing System also in use at MIT), was an early, revolutionary, and influential time-sharing operating system from MIT; it was developed principally by the Artificial Intelligence Laboratory at MIT, with some help from Project MAC.
Taken from Wikipedia