Bad substance for a 22-across

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Possible Answers: SALT.

Random information on the term “SALT”:

The Comprehensive Nuclear-Test-Ban Treaty (CTBT) is a multilateral treaty by which states agree to ban all nuclear explosions in all environments, for military or civilian purposes. It was adopted by the United Nations General Assembly on 10 September 1996[1] but it has not entered into force due to the non-ratification of eight specific states.
Taken from Wikipedia