“Why the troubled look?” … or a hint to 17-, 24-, 48- and 58-Across

This crossword clue is for the definition: “Why the troubled look?” … or a hint to 17-, 24-, 48- and 58-Across.
it’s A 67 letters crossword puzzle definition.
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Possible Answers: WHAT’S BUGGING YOU?.

Last seen on: NY Times Crossword 7 Nov 22, Monday